Role of CCK1 receptor in metabolic benefits of intestinal enteropeptidase inhibition in mice

Kamal Albarazanji; Simon Amadeus Hinke; Cassandre Cavanaugh; Jianying Liu; Stephen Beck; Neetu Shukla; Rong Meng; George Ho; Raul C. Camacho; James Leonard; Andrea R. Nawrocki

doi:10.1371/journal.pone.0312927

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Open Access

Peer-reviewed

Research Article

Role of CCK1 receptor in metabolic benefits of intestinal enteropeptidase inhibition in mice

Kamal Albarazanji,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America

https://orcid.org/0009-0005-4232-0197

⨯
Simon Amadeus Hinke,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America

https://orcid.org/0000-0003-4464-1929

⨯
Cassandre Cavanaugh,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
Jianying Liu,

Roles Investigation, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
Stephen Beck,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
Neetu Shukla,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
Rong Meng,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
George Ho,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
Raul C. Camacho,

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

Current Address: Madrigal Pharmaceuticals, Conshohocken, Pennsylvania, United States of America

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
James Leonard,

Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

Current Address: Crinetics Pharmaceuticals, San Diego, California, United States of America

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America
⨯
Andrea R. Nawrocki

Roles Conceptualization, Formal analysis, Project administration, Writing – original draft, Writing – review & editing

* E-mail: anawrock@its.jnj.com (ARN)

Affiliation Janssen Pharmaceutical Companies of Johnson & Johnson, Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Therapeutic Area, Spring House, Pennsylvania, United States of America

https://orcid.org/0000-0003-1348-3999

⨯

Role of CCK1 receptor in metabolic benefits of intestinal enteropeptidase inhibition in mice

Kamal Albarazanji,
Simon Amadeus Hinke,
Cassandre Cavanaugh,
Jianying Liu,
Stephen Beck,
Neetu Shukla,
Rong Meng,
George Ho,
Raul C. Camacho,
James Leonard

Published: June 3, 2025
https://doi.org/10.1371/journal.pone.0312927

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