SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau

• Motoki Imai,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliations Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Applied Tumor Pathology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

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• Fumitaka Kawakami,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Health Administration, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

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• Takayuki Uematsu,

  Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Biomedical Laboratory, Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Saitama, Japan

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• Toshihide Matsumoto,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Pathology, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

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• Rei Kawashima,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Biochemistry, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

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• Yoshifumi Kurosaki,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Clinical Chemistry, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

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• Shun Tamaki,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Biochemistry, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

  https://orcid.org/0009-0009-7722-5623

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• Shotaro Maehana,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan

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• Takafumi Ichikawa,

  Roles Supervision, Validation, Writing – review & editing

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Biochemistry, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan

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• Hideaki Hanaki,

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  Affiliation Infection Control Research Center, Ōmura Satoshi Memorial Institute, Kitasato University, Minato-Ku, Tokyo, Japan

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• Hidero Kitazato,

  Roles Resources, Supervision, Validation, Writing – review & editing

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan

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• Makoto Kubo

  Roles Investigation, Methodology, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: kuboma@kitasato-u.ac.jp

  Affiliations Regenerative Medicine and Cell Design Research Facility, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan, Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan

  https://orcid.org/0000-0001-8264-1343

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