Targeting long non-coding RNA RP11-502I4.3 inhibits the trend of angiogenesis in diabetic retinopathy

Lan Zeng; Yuhao Wu; Lijuan Zhu; Junhao He; Yuan Yuan; Xiaocong Wang; Kai Tang; Wei Tan

doi:10.1371/journal.pone.0312791

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Open Access

Peer-reviewed

Research Article

Targeting long non-coding RNA RP11-502I4.3 inhibits the trend of angiogenesis in diabetic retinopathy

Lan Zeng ,

Contributed equally to this work with: Lan Zeng, Yuhao Wu

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft

Affiliation Department of Ophthalmology, The First People’s Hospital of Zunyi (also known as The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China
⨯
Yuhao Wu ,

Contributed equally to this work with: Lan Zeng, Yuhao Wu

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft

Affiliation Zunyi Medical University, Zunyi, China
⨯
Lijuan Zhu,

Roles Data curation

Affiliation Zunyi Medical University, Zunyi, China
⨯
Junhao He,

Roles Formal analysis

Affiliations Department of Ophthalmology, The First People’s Hospital of Zunyi (also known as The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China, Scientific Research Center, The First People’s Hospital of Zunyi (also known as The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China
⨯
Yuan Yuan,

Roles Software

Affiliation Department of Ophthalmology, The First People’s Hospital of Zunyi (also known as The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China
⨯
Xiaocong Wang,

Roles Validation

Affiliation Department of Ophthalmology, The First People’s Hospital of Zunyi (also known as The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China
⨯
Kai Tang,

Roles Visualization

Affiliations Zunyi Medical University, Zunyi, China, Department of Ophthalmology, Heyou Hospital, Foshan, China.
⨯
Wei Tan

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: tanweichn@126.com

Affiliation Department of Ophthalmology, The First People’s Hospital of Zunyi (also known as The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China

https://orcid.org/0000-0003-2352-4379

⨯

Targeting long non-coding RNA RP11-502I4.3 inhibits the trend of angiogenesis in diabetic retinopathy

Lan Zeng,
Yuhao Wu,
Lijuan Zhu,
Junhao He,
Yuan Yuan,
Xiaocong Wang,
Kai Tang,
Wei Tan

Published: May 14, 2025
https://doi.org/10.1371/journal.pone.0312791

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Diabetes mellitus
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Long non-coding RNA
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Angiogenesis
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Retina
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Vasculogenesis
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Diabetic retinopathy
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Polymerase chain reaction
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Retinal ganglion cells
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