Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in Glioblastoma

Han Cheng; Yan Yan; Biao Zhang; Zhuolin Ma; Siwen Fu; Zhi Ji; Ziyi Zou; Qin Wang

doi:10.1371/journal.pone.0312764

Loading metrics

Open Access

Peer-reviewed

Research Article

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in Glioblastoma

Han Cheng ,

Roles Data curation, Methodology, Software, Writing – original draft

¶‡ The First Author.

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Yan Yan,

Roles Data curation, Resources, Software, Writing – original draft

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Biao Zhang,

Roles Software, Supervision

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Zhuolin Ma,

Roles Data curation, Formal analysis, Software

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Siwen Fu,

Roles Data curation, Methodology, Software, Writing – original draft

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Zhi Ji,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Ziyi Zou,

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China
⨯
Qin Wang

Roles Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: tjhhhospitallab@126.com

Affiliation Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China

https://orcid.org/0009-0002-2767-2432

⨯

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in Glioblastoma

Han Cheng,
Yan Yan,
Biao Zhang,
Zhuolin Ma,
Siwen Fu,
Zhi Ji,
Ziyi Zou,
Qin Wang

Published: April 7, 2025
https://doi.org/10.1371/journal.pone.0312764

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

NK cells
Is the Subject Area "NK cells" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Cancer immunotherapy
Is the Subject Area "Cancer immunotherapy" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Glioma cells
Is the Subject Area "Glioma cells" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Bone marrow cells
Is the Subject Area "Bone marrow cells" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.