Using intrahost single nucleotide variant data to predict SARS-CoV-2 detection cycle threshold values

Lea Duesterwald; Marcus Nguyen; Paul Christensen; S. Wesley Long; Randall J. Olsen; James M. Musser; James J. Davis

doi:10.1371/journal.pone.0312686

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Open Access

Peer-reviewed

Research Article

Using intrahost single nucleotide variant data to predict SARS-CoV-2 detection cycle threshold values

Lea Duesterwald,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations College of Engineering, Cornell University, Ithaca, NY, United States of America, Northwestern-Argonne Institute for Science and Engineering, Evanston, IL, United States of America
⨯
Marcus Nguyen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Northwestern-Argonne Institute for Science and Engineering, Evanston, IL, United States of America, Data Science and Learning Division, Argonne National Laboratory, Lemont, IL, United States of America, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, United States of America
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Paul Christensen,

Roles Data curation, Methodology, Project administration, Resources, Writing – review & editing

Affiliations Laboratory of Human Molecular and Translational Human Infectious Diseases, Center for Infectious Diseases, Houston Methodist Research Institute and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United States of America, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, United States of America
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S. Wesley Long,

Roles Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Laboratory of Human Molecular and Translational Human Infectious Diseases, Center for Infectious Diseases, Houston Methodist Research Institute and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United States of America, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, United States of America
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Randall J. Olsen,

Roles Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Laboratory of Human Molecular and Translational Human Infectious Diseases, Center for Infectious Diseases, Houston Methodist Research Institute and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United States of America, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, United States of America
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James M. Musser,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Laboratory of Human Molecular and Translational Human Infectious Diseases, Center for Infectious Diseases, Houston Methodist Research Institute and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, United States of America, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, United States of America
⨯
James J. Davis

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jjdavis@anl.gov

Affiliations Northwestern-Argonne Institute for Science and Engineering, Evanston, IL, United States of America, Data Science and Learning Division, Argonne National Laboratory, Lemont, IL, United States of America, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, United States of America

https://orcid.org/0000-0003-0435-6891

⨯

Using intrahost single nucleotide variant data to predict SARS-CoV-2 detection cycle threshold values

Lea Duesterwald,
Marcus Nguyen,
Paul Christensen,
S. Wesley Long,
Randall J. Olsen,
James M. Musser,
James J. Davis

Published: October 30, 2024
https://doi.org/10.1371/journal.pone.0312686

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