Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

• Matthew D. Gregory ,

  Contributed equally to this work with: Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institute of Public Health, Florida A&M University College of Pharmacy Pharmaceutical Sciences, Tallahassee, FL, United States of America

  ⨯
• Kweku Ofosu-Asante ,

  Contributed equally to this work with: Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Institute of Public Health, Florida A&M University College of Pharmacy Pharmaceutical Sciences, Tallahassee, FL, United States of America

  ⨯
• Jassy Mary S. Lazarte ,

  Contributed equally to this work with: Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte

  Roles Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Institute of Public Health, Florida A&M University College of Pharmacy Pharmaceutical Sciences, Tallahassee, FL, United States of America

  ⨯
• Pablo E. Puente ,

  Roles Validation, Writing – review & editing

  ¶‡ These authors also equally contributed to this work

  Affiliation Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, United States of America

  ⨯
• Nada Tawfeeq,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Current address: College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

  Affiliation Institute of Public Health, Florida A&M University College of Pharmacy Pharmaceutical Sciences, Tallahassee, FL, United States of America

  ⨯
• Nadine Belony ,

  Roles Validation, Writing – review & editing

  ¶‡ These authors also equally contributed to this work

  Affiliation University of Florida Department of Mechanical and Aerospace Engineering, Gainesville, FL, United States of America

  ⨯
• Yong Huang ,

  Roles Funding acquisition, Supervision, Validation, Writing – review & editing

  ¶‡ These authors also equally contributed to this work

  Affiliation University of Florida Department of Mechanical and Aerospace Engineering, Gainesville, FL, United States of America

  ⨯
• Ite A. Offringa ,

  Roles Formal analysis, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

  ¶‡ These authors also equally contributed to this work

  Affiliation Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, United States of America

  ⨯
• Nazarius S. Lamango

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: nazarius.lamango@famu.edu

  Affiliation Institute of Public Health, Florida A&M University College of Pharmacy Pharmaceutical Sciences, Tallahassee, FL, United States of America

  https://orcid.org/0000-0002-4906-8933

  ⨯