Direct activation of HSF1 by macromolecular crowding and misfolded proteins

Oliver Simoncik; Vlastimil Tichy; Michal Durech; Lenka Hernychova; Filip Trcka; Lukas Uhrik; Miroslav Bardelcik; Philip J. Coates; Borivoj Vojtesek; Petr Muller

doi:10.1371/journal.pone.0312524

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Open Access

Peer-reviewed

Research Article

Direct activation of HSF1 by macromolecular crowding and misfolded proteins

Oliver Simoncik,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliations Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
⨯
Vlastimil Tichy,

Roles Investigation, Methodology

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Michal Durech,

Roles Investigation, Methodology

Current address: Department of Hematooncology, University of Ostrava, Ostrava, Czech Republic

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Lenka Hernychova,

Roles Investigation, Validation

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic

https://orcid.org/0000-0002-4352-0626

⨯
Filip Trcka,

Roles Investigation, Methodology

Current address: Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Lukas Uhrik,

Roles Investigation, Methodology

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic

https://orcid.org/0000-0002-6077-4249

⨯
Miroslav Bardelcik,

Roles Investigation, Methodology

Affiliations Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic, Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
⨯
Philip J. Coates,

Roles Writing – review & editing

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Borivoj Vojtesek,

Roles Funding acquisition, Supervision

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Petr Muller

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft

* E-mail: muller@mou.cz

Affiliation Research Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic

https://orcid.org/0000-0002-8404-4494

⨯

Direct activation of HSF1 by macromolecular crowding and misfolded proteins

Oliver Simoncik,
Vlastimil Tichy,
Michal Durech,
Lenka Hernychova,
Filip Trcka,
Lukas Uhrik,
Miroslav Bardelcik,
Philip J. Coates,
Borivoj Vojtesek,
Petr Muller

Published: November 4, 2024
https://doi.org/10.1371/journal.pone.0312524

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Monomers
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DNA-binding proteins
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Protein folding
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