A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions

• Sedem Dankwa ,

  Contributed equally to this work with: Sedem Dankwa, Christina Kosman, Maria Dennis

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Christina Kosman ,

  Contributed equally to this work with: Sedem Dankwa, Christina Kosman, Maria Dennis

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Maria Dennis ,

  Contributed equally to this work with: Sedem Dankwa, Christina Kosman, Maria Dennis

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Elena E. Giorgi,

  Roles Formal analysis, Software, Validation, Writing – review & editing

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America

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• Kenneth Vuong,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Ioanna Pahountis,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Ashley Garza,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Surgery, Duke University School of Medicine, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States of America

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• Christian Binuya,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Janice McCarthy,

  Roles Formal analysis, Investigation, Methodology, Software, Writing – review & editing

  Affiliations Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, United States of America, Center for Human Systems Immunology, Duke University, Durham, NC, United States of America

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• Bryan T. Mayer,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America

  https://orcid.org/0000-0003-2258-5276

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• Julia T. Ngo,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, United States of America

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• Chiamaka A. Enemuo,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, United States of America

  ⨯
• Diane G. Carnathan,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, United States of America

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• Sherry Stanfield-Oakley,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Surgery, Duke University School of Medicine, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States of America

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• Stella J. Berendam,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States of America

  ⨯
• Carolyn Weinbaum,

  Roles Data curation, Project administration, Validation, Writing – review & editing

  Affiliation Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America

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• Kathleen Engelman,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, UMass Chan Medical School, Worcester, MA, United States of America

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• Diogo M. Magnani,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, UMass Chan Medical School, Worcester, MA, United States of America

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• Cliburn Chan,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, United States of America, Center for Human Systems Immunology, Duke University, Durham, NC, United States of America

  ⨯
• Guido Ferrari,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Surgery, Duke University School of Medicine, Durham, NC, United States of America, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States of America

  ⨯
• Guido Silvestri,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, United States of America, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States of America

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• Rama R. Amara,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, United States of America, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States of America

  ⨯
• Ann Chahroudi,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States of America, Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta and Emory University, Atlanta, GA, United States of America

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• Sallie R. Permar,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America, Gale and Ira Drukier Institute for Children’s Health, Weill Cornell Medicine, New York, NY, United States of America

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• Genevieve G. Fouda,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America, Gale and Ira Drukier Institute for Children’s Health, Weill Cornell Medicine, New York, NY, United States of America

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•  [ ... ],
• Ria Goswami

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rig4007@med.cornell.edu

  Affiliations Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America, Gale and Ira Drukier Institute for Children’s Health, Weill Cornell Medicine, New York, NY, United States of America

  https://orcid.org/0000-0002-4574-5431

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