Predictive immunoinformatics reveal promising safety and anti-onchocerciasis protective immune response profiles to vaccine candidates (Ov-RAL-2 and Ov-103) in anticipation of phase I clinical trials

• Derrick Neba Nebangwa ,

  Contributed equally to this work with: Derrick Neba Nebangwa, Robert Adamu Shey

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: neba.nebangwa@ubuea.cm (DNN); stephen.ghogomu@ubuea.cm (SMG); fidele.ntie-kang@ubuea.cm (FNK)

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon

  https://orcid.org/0000-0002-5815-5705

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• Robert Adamu Shey ,

  Contributed equally to this work with: Derrick Neba Nebangwa, Robert Adamu Shey

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon, Tropical Disease Interventions, Diagnostics, Vaccines and Therapeutics (TroDDIVaT) Initiative, Buea, Cameroon

  https://orcid.org/0000-0003-0146-3894

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• Daniel Madulu Shadrack,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, St. John’s University of Tanzania, Dodoma, Tanzania

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• Cabirou Mounchili Shintouo,

  Roles Data curation, Investigation

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon

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• Ntang Emmaculate Yaah,

  Roles Data curation

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon

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• Bernis Neneyoh Yengo,

  Roles Data curation

  Affiliation Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania, United States of America

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• Mary Teke Efeti,

  Roles Data curation, Investigation

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon

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• Ketura Yaje Gwei,

  Roles Data curation

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon

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• Darling Bih Aubierge Fomekong,

  Roles Data curation

  Affiliation Department of Nursing, Mount Zion Higher Institute, Mankon, Bamenda, Cameroon

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• Gordon Takop Nchanji,

  Roles Data curation

  Affiliations Tropical Disease Interventions, Diagnostics, Vaccines and Therapeutics (TroDDIVaT) Initiative, Buea, Cameroon, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon

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• Arnaud Azonpi Lemoge,

  Roles Data curation, Investigation

  Affiliation Ngonpong Therapeutics, Concord Pike, Wilmington, Delaware, United States of America

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• Fidele Ntie‑Kang ,

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: neba.nebangwa@ubuea.cm (DNN); stephen.ghogomu@ubuea.cm (SMG); fidele.ntie-kang@ubuea.cm (FNK)

  Affiliations Center for Drug Discovery, University of Buea, Buea, Cameroon, Department of Chemistry, University of Buea, Buea, Cameroon, Institute of Pharmacy, Martin‑Luther University of Halle‑Wittenberg, Halle, Germany

  https://orcid.org/0000-0003-0795-394X

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• Stephen Mbigha Ghogomu

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: neba.nebangwa@ubuea.cm (DNN); stephen.ghogomu@ubuea.cm (SMG); fidele.ntie-kang@ubuea.cm (FNK)

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea, Cameroon

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