Interaction between CD244 and SHP2 regulates inflammation in chronic obstructive pulmonary disease via targeting the MAPK/NF-κB signaling pathway

Xiaobing Gao; Suhua Shao; Xi Zhang; Changjie Li; Qianqian Jiang; Bo Li

doi:10.1371/journal.pone.0312228

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Open Access

Peer-reviewed

Research Article

Interaction between CD244 and SHP2 regulates inflammation in chronic obstructive pulmonary disease via targeting the MAPK/NF-κB signaling pathway

Xiaobing Gao ,

Contributed equally to this work with: Xiaobing Gao, Suhua Shao, Xi Zhang

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Emergency Medicine, General Hospital of Central Theater Command, Wuhan, Hubei Province, China
⨯
Suhua Shao ,

Contributed equally to this work with: Xiaobing Gao, Suhua Shao, Xi Zhang

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Emergency Medicine, General Hospital of Central Theater Command, Wuhan, Hubei Province, China
⨯
Xi Zhang ,

Contributed equally to this work with: Xiaobing Gao, Suhua Shao, Xi Zhang

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Department of Outpatient, General Hospital of Central Theater Command, Wuhan, Hubei Province, China
⨯
Changjie Li,

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Shanghai Yijian Medical Testing Institute, Shanghai, China
⨯
Qianqian Jiang ,

Roles Conceptualization, Funding acquisition, Supervision

* E-mail: kreuz-kreuz@163.com (BL); whdxrmyyjqq@163.com (QJ)

Affiliation Health Management Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China

https://orcid.org/0009-0003-3568-2953

⨯
Bo Li

Roles Investigation, Project administration, Supervision, Validation

* E-mail: kreuz-kreuz@163.com (BL); whdxrmyyjqq@163.com (QJ)

Affiliation Department of Emergency Medicine, General Hospital of Central Theater Command, Wuhan, Hubei Province, China
⨯

Interaction between CD244 and SHP2 regulates inflammation in chronic obstructive pulmonary disease via targeting the MAPK/NF-κB signaling pathway

Xiaobing Gao,
Suhua Shao,
Xi Zhang,
Changjie Li,
Qianqian Jiang,
Bo Li

Published: October 18, 2024
https://doi.org/10.1371/journal.pone.0312228

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Chronic obstructive pulmonary disease
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Inflammation
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Apoptosis
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MAPK signaling cascades
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Enzyme-linked immunoassays
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