A novel oncolytic vaccinia virus with multiple gene modifications involved in viral replication and maturation increases safety for intravenous administration while maintaining proliferative potential in cancer cells

• Go Okita ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: okita-go@kmbiologics.com

  Affiliation Research Department, KM Biologics Co., Ltd., Kikuchi, Kumamoto, Japan

  https://orcid.org/0009-0005-6500-7267

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• Kiyotaka Suenaga,

  Roles Investigation, Methodology, Writing – review & editing

  Current address: Development Department, Meiji Animal Health Co., Ltd., Kumamoto, Japan

  Affiliation Research Department, KM Biologics Co., Ltd., Kikuchi, Kumamoto, Japan

  https://orcid.org/0000-0003-2075-8591

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• Masashi Sakaguchi,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Research Department, KM Biologics Co., Ltd., Kikuchi, Kumamoto, Japan

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• Toshio Murakami

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Research Department, KM Biologics Co., Ltd., Kikuchi, Kumamoto, Japan

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