Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration

• Naoto Arimura ,

  Contributed equally to this work with: Naoto Arimura, Hideki Matsui

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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• Chie Maeda,

  Roles Investigation, Methodology

  Current address: Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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• Kazunobu Aoyama,

  Roles Data curation, Investigation, Methodology

  Current address: Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa, Japan

  Affiliation DMPK, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

  https://orcid.org/0000-0001-5824-4831

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• Namiko Yamaguchi,

  Roles Investigation, Writing – review & editing

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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• Ayumu Sugiura,

  Roles Data curation, Investigation

  Affiliation Computational Biology, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

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• Yasuko Takahashi,

  Roles Investigation

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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• Ryouta Maeda,

  Roles Investigation, Methodology

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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• Tatsuya Ando,

  Roles Supervision

  Affiliation Computational Biology, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

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• Makoto Kamata,

  Roles Supervision

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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• Hideki Matsui ,

  Contributed equally to this work with: Naoto Arimura, Hideki Matsui

  Roles Conceptualization, Data curation, Project administration, Writing – review & editing

  * E-mail: hideki.matsui@takeda.com

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

  https://orcid.org/0000-0003-4856-4465

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• Maiko Tanaka

  Roles Supervision, Writing – review & editing

  Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Kanagawa, Japan

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