Do we still need a canary in the coal mine for laboratory animal facilities? A systematic review of environmental health monitoring versus soiled bedding sentinels

• Megan R. LaFollette ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: meglafollette@3rc.org

  Affiliation The 3Rs Collaborative, Denver, Colorado, United States of America

  https://orcid.org/0000-0003-0643-2210

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• Caroline S. Clement,

  Roles Data curation, Methodology, Writing – original draft

  Affiliations Department of Comparative Medicine, Stanford University, Stanford, CA, United States of America, Department of Biology, Stanford University, Stanford, CA, United States of America

  https://orcid.org/0009-0008-8831-793X

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• Kerith R. Luchins,

  Roles Conceptualization, Investigation, Validation, Writing – review & editing

  Affiliation Animal Resources Center and Department of Surgery, University of Chicago, Chicago, IL, United States of America

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• Christopher A. Manuel,

  Roles Conceptualization, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Office of Laboratory Animal Resources, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America

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• Patricia L. Foley,

  Roles Conceptualization, Investigation, Validation, Writing – review & editing

  Affiliation Animal Models Shared Resources, Georgetown University Medical Center, Washington, DC, United States of America

  https://orcid.org/0000-0001-5735-9485

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• Wai H. Hanson,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Division of Animal Resources, Emory University, Atlanta, GA, United States of America

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• Christina Pettan-Brewer,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, United States of America

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• Caroline B. Winn,

  Roles Conceptualization, Validation, Writing – original draft, Writing – review & editing

  Affiliation Comparative Medicine, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, United States of America

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• Joseph P. Garner

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Comparative Medicine, Stanford University, Stanford, CA, United States of America, Department of Psychiatry and Behavioral Sciences (By Courtesy), Stanford University, Stanford, CA, United States of America

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