Synthesis of novel N-substituted β-amino acid derivatives bearing 2-hydroxyphenyl moieties as promising antimicrobial candidates targeting multidrug-resistant Gram-positive pathogens

• Povilas Kavaliauskas ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: povilas.kavaliauskas@som.umaryland.edu

  Affiliations Department of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, United States of America, Institute of Infectious Diseases and Pathogenic Microbiology, Prienai, Lithuania, Biological Research Center, Lithuanian University of Health Sciences, Kaunas, Lithuania

  https://orcid.org/0000-0003-0237-9088

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• Birutė Grybaitė,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania

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• Birute Sapijanskaite-Banevič,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania

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• Rūta Petraitienė,

  Roles Formal analysis, Investigation

  Affiliations Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, United States of America, Institute of Infectious Diseases and Pathogenic Microbiology, Prienai, Lithuania, Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, United States of America

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• Ramunė Grigalevičiūtė,

  Roles Investigation

  Affiliations Biological Research Center, Lithuanian University of Health Sciences, Kaunas, Lithuania, Department of Animal Nutrition, Lithuanian University of Health Sciences, Kaunas, Lithuania

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• Andrew Garcia,

  Roles Formal analysis, Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, United States of America

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• Ethan Naing,

  Roles Formal analysis, Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, United States of America

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• Vytautas Mickevičius ,

  Contributed equally to this work with: Vytautas Mickevičius, Vidmantas Petraitis

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliation Department of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania

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• Sergey Belyakov,

  Roles Investigation

  Affiliation Latvian Institute of Organic Synthesis, Laboratory of Physical Organic Chemistry, Riga, Latvia

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• Vidmantas Petraitis

  Contributed equally to this work with: Vytautas Mickevičius, Vidmantas Petraitis

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliations Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, United States of America, Institute of Infectious Diseases and Pathogenic Microbiology, Prienai, Lithuania, Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, United States of America

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