n-Butylidenephthalide recovered calcium homeostasis to ameliorate neurodegeneration of motor neurons derived from amyotrophic lateral sclerosis iPSCs

• Yu-Chen Deng,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemical and Molecular Medical Sciences, National Dong Hwa University, Hualien, Taiwan, Everfront Biotech Inc., Taipei, Taiwan

  https://orcid.org/0009-0001-3392-0765

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• Jen-Wei Liu,

  Roles Formal analysis, Methodology, Writing – original draft

  Affiliation Everfront Biotech Inc., Taipei, Taiwan

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• Hsiao-Chien Ting,

  Roles Methodology

  Affiliation Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

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• Tzu-Chen Kuo,

  Roles Investigation, Validation, Visualization

  Affiliation Department of Biochemical and Molecular Medical Sciences, National Dong Hwa University, Hualien, Taiwan

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• Chia-Hung Chiang,

  Roles Formal analysis, Investigation

  Affiliation Department of Biochemical and Molecular Medical Sciences, National Dong Hwa University, Hualien, Taiwan

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• En-Yi Lin,

  Roles Investigation, Methodology

  Affiliations Department of Biochemical and Molecular Medical Sciences, National Dong Hwa University, Hualien, Taiwan, Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

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• Horng-Jyh Harn,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, Department of Pathology, Hualien Tzu Chi Hospital, Hualien, Taiwan

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• Shinn-Zong Lin,

  Roles Resources

  Affiliations Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, Taiwan

  https://orcid.org/0000-0002-4601-9933

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• Chia-Yu Chang ,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: twchiou@gms.ndhu.edu.tw (T-WC); scata0726@gmail.com (C-YC)

  Affiliations Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan, Department of Medical Research, Hualien Tzu Chi Hospital, Hualien, Taiwan

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• Tzyy-Wen Chiou

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: twchiou@gms.ndhu.edu.tw (T-WC); scata0726@gmail.com (C-YC)

  Affiliation Department of Biochemical and Molecular Medical Sciences, National Dong Hwa University, Hualien, Taiwan

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