Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells

• Rachel B. Gilmore ,

  Contributed equally to this work with: Rachel B. Gilmore, Dea Gorka

  Roles Data curation, Formal analysis, Investigation, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, United States of America, Graduate Program in Biomedical Science, Genetics and Developmental Biology, UConn Health, Farmington, CT, United States of America

  https://orcid.org/0000-0001-7435-263X

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• Dea Gorka ,

  Contributed equally to this work with: Rachel B. Gilmore, Dea Gorka

  Roles Formal analysis, Investigation, Resources, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, United States of America, Graduate Program in Biomedical Science, Genetics and Developmental Biology, UConn Health, Farmington, CT, United States of America

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• Christopher E. Stoddard,

  Roles Resources, Writing – review & editing

  Affiliation Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, United States of America

  https://orcid.org/0000-0002-7137-761X

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• Pooja Sonawane,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, United States of America, Graduate Program in Biomedical Science, Genetics and Developmental Biology, UConn Health, Farmington, CT, United States of America

  https://orcid.org/0009-0003-3485-416X

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• Justin Cotney ,

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: cotneyj@chop.edu (JC); stormy.chamberlain@roche.com (SJC)

  ¶‡ JC and SJC also contributed equally to this work.

  Affiliations Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, United States of America, Institute for Systems Genomics, University of Connecticut, Storrs, CT, United States of America

  https://orcid.org/0000-0001-8230-2157

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• Stormy J. Chamberlain

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: cotneyj@chop.edu (JC); stormy.chamberlain@roche.com (SJC)

  ¶‡ JC and SJC also contributed equally to this work.

  Affiliations Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, United States of America, Institute for Systems Genomics, University of Connecticut, Storrs, CT, United States of America

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