Notch dimerization provides robustness against environmental insults and is required for vascular integrity

• Kristina Preusse ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Rafi.kopan@gmail.com (RK); Kristina.Preusse@cchmc.org (KP)

  Affiliation Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0003-3374-4498

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• Kim Cochran,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

  ⨯
• Quanhui Dai,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliations Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, State Key Laboratory of Genetic Engineering, School of Life Sciences, Greater Bay Area Institute of Precision Medicine (Guangzhou), Zhongshan Hospital, Fudan University, Shanghai, China

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• Raphael Kopan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: Rafi.kopan@gmail.com (RK); Kristina.Preusse@cchmc.org (KP)

  Affiliation Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0002-0350-2730

  ⨯