Study protocol: Exploratory trial of Forza™, an osmotin-based nutraceutical as adjuvant for the treatment of progressive multiple sclerosis

• Viola Costa,

  Roles Data curation, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy

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• Kenda Aluan,

  Roles Data curation, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy

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• Irene Schiavetti,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Health Sciences, Section of Biostatistics, University of Genoa, Genoa, Italy

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• Caterina Bason,

  Roles Investigation, Writing – review & editing

  Affiliation IRCCS, Ospedale Policlinico San Martino, Genova, Italy

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• Tiziana Vigo,

  Roles Investigation, Writing – review & editing

  Affiliation IRCCS, Ospedale Policlinico San Martino, Genova, Italy

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• Elisa Leveraro,

  Roles Investigation, Writing – review & editing

  Affiliation IRCCS, Ospedale Policlinico San Martino, Genova, Italy

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• Corrado Cabona,

  Roles Investigation, Writing – review & editing

  Affiliation IRCCS, Ospedale Policlinico San Martino, UOC Neurofisiopatologia, Genoa, Italy

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• Valeria Prada,

  Roles Investigation, Writing – review & editing

  Affiliation Italian Multiple Sclerosis Society Foundation (FISM), Scientific Research Area, Genoa, Italy

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• Mauro Costagli,

  Roles Methodology, Software, Writing – review & editing

  Affiliations Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy, IRCCS, Ospedale Policlinico San Martino, Genova, Italy

  https://orcid.org/0000-0001-9073-1082

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• Vincenzo Daniele Boccia,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy

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• Bruno Ruggiero,

  Roles Conceptualization, Resources, Supervision, Visualization, Writing – review & editing

  Affiliation 9th Dimension Biotech, Inc, McMinnville, Oregon, United States of America

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• Giampaolo Brichetto,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Associazione Italiana Sclerosi Multipla (AISM) Rehabilitation Center, Genoa, Italy

  https://orcid.org/0000-0003-2026-3572

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• Marco Salvetti,

  Roles Conceptualization, Data curation, Investigation, Supervision, Writing – review & editing

  Affiliations Centre for Experimental Neurological Therapies (CENTERS), Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University, Rome, Italy, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy

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• Maria Pia Sormani,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Health Sciences, Section of Biostatistics, University of Genoa, Genoa, Italy, IRCCS, Ospedale Policlinico San Martino, Genova, Italy

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• Gianluigi Mancardi,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy

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• Matilde Inglese ,

  Roles Conceptualization, Data curation, Investigation, Supervision, Visualization, Writing – review & editing

  * E-mail: m.inglese@unige.it

  Affiliations Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy, IRCCS, Ospedale Policlinico San Martino, Genova, Italy

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•  [ ... ],
• Mario Alberto Battaglia

  Roles Conceptualization, Supervision, Visualization, Writing – review & editing

  Affiliation Italian Multiple Sclerosis Society Foundation (FISM), Scientific Research Area, Genoa, Italy

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