Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14^Δ/+ mice hearts

• Brian Foo ,

  Contributed equally to this work with: Brian Foo, Hugo Amedei

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft

  * E-mail: brian.foo@med.uni-goettingen.de (BF); christof.lenz@mpinat.mpg.de, christof.lenz@med.uni-goettingen.de (CL); slehnart@med.uni-goettingen.de (SEL)

  Affiliations Department of Cardiology and Pneumology, Heart Research Center Göttingen, Cellular Biophysics and Translational Cardiology Section, University Medical Center Göttingen, Göttingen, Germany, Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany

  https://orcid.org/0009-0004-1361-0382

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• Hugo Amedei ,

  Contributed equally to this work with: Brian Foo, Hugo Amedei

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Department of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany

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• Surmeet Kaur,

  Roles Formal analysis, Investigation

  Current address: Institute of Medical Virology, Justus Liebig University, Giessen, Germany.

  Affiliation Department of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany

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• Samir Jaawan,

  Roles Formal analysis, Investigation

  Affiliations Department of Cardiology and Pneumology, Heart Research Center Göttingen, Cellular Biophysics and Translational Cardiology Section, University Medical Center Göttingen, Göttingen, Germany, Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany

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• Angela Boshnakovska,

  Roles Formal analysis, Investigation

  Affiliation Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany

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• Tanja Gall,

  Roles Formal analysis, Investigation

  Affiliation Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany

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• Rudolf A. de Boer,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, Rotterdam, the Netherlands

  https://orcid.org/0000-0002-4775-9140

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• Herman H. W. Silljé,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

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• Henning Urlaub,

  Roles Writing – review & editing

  Affiliations Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany, Department of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany, Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany

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• Peter Rehling,

  Roles Formal analysis, Investigation

  Affiliation Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany

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• Christof Lenz ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: brian.foo@med.uni-goettingen.de (BF); christof.lenz@mpinat.mpg.de, christof.lenz@med.uni-goettingen.de (CL); slehnart@med.uni-goettingen.de (SEL)

  Affiliations Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany, Department of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany, Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany

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• Stephan E. Lehnart

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: brian.foo@med.uni-goettingen.de (BF); christof.lenz@mpinat.mpg.de, christof.lenz@med.uni-goettingen.de (CL); slehnart@med.uni-goettingen.de (SEL)

  Affiliations Department of Cardiology and Pneumology, Heart Research Center Göttingen, Cellular Biophysics and Translational Cardiology Section, University Medical Center Göttingen, Göttingen, Germany, Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany

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