Efficacy of mefloquine and its enantiomers in a murine model of Mycobacterium avium infection

Antoine Froment; Julia Delomez; Sophie Da Nascimento; Alexandra Dassonville-Klimpt; Claire Andréjak; François Peltier; Cédric Joseph; Pascal Sonnet; Jean-Philippe Lanoix

doi:10.1371/journal.pone.0311167

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Open Access

Peer-reviewed

Research Article

Efficacy of mefloquine and its enantiomers in a murine model of Mycobacterium avium infection

Antoine Froment,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France, Infectious Disease Department, Amiens-Picardie University Hospital, Amiens, France

https://orcid.org/0000-0001-5185-8590

⨯
Julia Delomez,

Roles Data curation, Investigation, Methodology, Software, Validation

Affiliations AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France, Pneumology Department, Amiens-Picardie University Hospital, Amiens, France
⨯
Sophie Da Nascimento,

Roles Investigation, Validation

Affiliation AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France
⨯
Alexandra Dassonville-Klimpt,

Roles Conceptualization, Investigation, Methodology, Validation

Affiliation AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France
⨯
Claire Andréjak,

Roles Conceptualization, Funding acquisition, Resources, Validation, Writing – review & editing

Affiliations AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France, Pneumology Department, Amiens-Picardie University Hospital, Amiens, France
⨯
François Peltier,

Roles Investigation, Resources, Software

Affiliation AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France
⨯
Cédric Joseph,

Roles Investigation, Writing – review & editing

Affiliation Infectious Disease Department, Amiens-Picardie University Hospital, Amiens, France
⨯
Pascal Sonnet,

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

Affiliation AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France
⨯
Jean-Philippe Lanoix

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: lanoix.jean-philippe@chu-amiens.fr

Affiliations AGIR UR-4294, Université de Picardie Jules Verne, Amiens, France, Infectious Disease Department, Amiens-Picardie University Hospital, Amiens, France
⨯

Efficacy of mefloquine and its enantiomers in a murine model of Mycobacterium avium infection

Antoine Froment,
Julia Delomez,
Sophie Da Nascimento,
Alexandra Dassonville-Klimpt,
Claire Andréjak,
François Peltier,
Cédric Joseph,
Pascal Sonnet,
Jean-Philippe Lanoix

Published: September 30, 2024
https://doi.org/10.1371/journal.pone.0311167

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Mycobacterium avium complex
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Enantiomers
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Animal models of infection
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Antibiotics
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Respiratory infections
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Mefloquine
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