Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation

Bo Xiong; Mingjie Fan; Zhihui Wang; Xiaolu Yang; Shan Cao; Jie Shen; Beibei Fan

doi:10.1371/journal.pone.0311152

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Open Access

Peer-reviewed

Research Article

Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation

Bo Xiong ,

Contributed equally to this work with: Bo Xiong, Mingjie Fan

Roles Data curation, Investigation, Methodology

Affiliation Department of Clinical Pharmacy, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Mingjie Fan ,

Contributed equally to this work with: Bo Xiong, Mingjie Fan

Roles Data curation, Funding acquisition, Investigation

Affiliation Department of Pharmacy, Shanghai Fourth Rehabilitation Hospital, Shanghai, China
⨯
Zhihui Wang,

Roles Formal analysis, Investigation

Affiliation Department of Clinical Pharmacy, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Xiaolu Yang,

Roles Data curation, Validation

Affiliation Department of Clinical Pharmacy, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

https://orcid.org/0009-0009-1470-9858

⨯
Shan Cao,

Roles Data curation, Validation

Affiliation Department of Clinical Pharmacy, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Jie Shen ,

Roles Conceptualization, Project administration, Supervision, Writing – original draft

* E-mail: jessiefan2012@163.com (BF); shj421@126.com (JS)

¶‡ BF and JS also contributed equally to this work.

Affiliation Department of Pharmacy, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
⨯
Beibei Fan

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: jessiefan2012@163.com (BF); shj421@126.com (JS)

¶‡ BF and JS also contributed equally to this work.

Affiliation Department of Clinical Pharmacy, Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China

https://orcid.org/0009-0005-3844-8008

⨯

Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation

Bo Xiong,
Mingjie Fan,
Zhihui Wang,
Xiaolu Yang,
Shan Cao,
Jie Shen,
Beibei Fan

Published: November 21, 2024
https://doi.org/10.1371/journal.pone.0311152

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