Metformin lotion promotes scarless skin tissue formation through AMPK activation, TGF-β1 inhibition, and reduced myofibroblast numbers

• Jianying Zhang,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliation MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Kengo Shimozaki,

  Roles Methodology, Validation

  Affiliation MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

  ⨯
• Soichi Hattori,

  Roles Methodology, Validation

  Affiliation MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

  ⨯
• Vasyl Pastukh,

  Roles Methodology, Validation

  Affiliation MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

  https://orcid.org/0000-0002-9854-8212

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• Derek Maloney,

  Roles Data curation, Methodology

  Affiliation MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

  https://orcid.org/0000-0002-1825-3757

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• MaCalus V. Hogan,

  Roles Writing – review & editing

  Affiliations MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States of America

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• James H-C. Wang

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: wanghc@pitt.edu

  Affiliations MechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United States of America

  https://orcid.org/0000-0001-7279-0679

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