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Open Access

Peer-reviewed

Research Article

Tumorigenicity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production

Jiahao Zheng ,

Contributed equally to this work with: Jiahao Zheng, Boran Li

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Boran Li ,

Contributed equally to this work with: Jiahao Zheng, Boran Li

Roles Supervision

Affiliation Medical Products Administration of Hubei Province, Wuhan, China
⨯
Lanxin Jia,

Roles Methodology, Software

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Jiayou Zhang,

Roles Conceptualization, Methodology, Supervision

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Zheng Gong,

Roles Conceptualization, Methodology

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Yang Le,

Roles Methodology, Software

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Xuanxuan Nian,

Roles Methodology, Supervision

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Xuedan Li,

Roles Methodology

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Bo Liu,

Roles Resources, Software

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Daiguan Yu,

Roles Conceptualization, Writing – review & editing

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China
⨯
Zhegang Zhang ,

Roles Conceptualization, Methodology, Writing – review & editing

* E-mail: changguili@aliyun.com (CL); zhangzhegang@sinopharm.com (ZZ)

Affiliations National Engineering Technology Research Center for Combined Vaccines, Wuhan, China, Wuhan Institute of Biological Products Co.Ltd., Wuhan, China

https://orcid.org/0000-0002-6085-9859

⨯
Changgui Li

Roles Supervision, Writing – review & editing

* E-mail: changguili@aliyun.com (CL); zhangzhegang@sinopharm.com (ZZ)

Affiliation National Institute for Food and Drug Control, Beijing, China
⨯

Tumorigenicity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production

Jiahao Zheng,
Boran Li,
Lanxin Jia,
Jiayou Zhang,
Zheng Gong,
Yang Le,
Xuanxuan Nian,
Xuedan Li,
Bo Liu,
Daiguan Yu

x

Published: December 16, 2024
https://doi.org/10.1371/journal.pone.0311069

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Lung and intrathoracic tumors
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