Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa

• Juan Andrés Imelio,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay

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• Felipe Trajtenberg,

  Roles Formal analysis, Investigation, Resources, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay

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• Sonia Mondino,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay

  https://orcid.org/0009-0002-8637-2210

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• Leticia Zarantonelli,

  Roles Investigation, Resources, Validation, Writing – review & editing

  Affiliation Unidad Mixta Pasteur INIA, Institut Pasteur de Montevideo, Montevideo, Uruguay

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• Iakov Vitrenko,

  Roles Investigation, Methodology

  Affiliation Plateforme Technologique Biomics, C2RT, Institut Pasteur, Université Paris Cité, Paris, France

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• Laure Lemée,

  Roles Investigation, Methodology

  Affiliation Plateforme Technologique Biomics, C2RT, Institut Pasteur, Université Paris Cité, Paris, France

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• Thomas Cokelaer,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Validation

  Affiliations Plateforme Technologique Biomics, C2RT, Institut Pasteur, Université Paris Cité, Paris, France, Bioinformatics and Biostatistics Hub, Institut Pasteur, Paris, France

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• Mathieu Picardeau,

  Roles Formal analysis, Funding acquisition, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliation Biology of Spirochetes Unit, Institut Pasteur, Université Paris Cité, Paris, France

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• Alejandro Buschiazzo

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: alebus@pasteur.edu.uy

  Affiliations Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay, Dept of Microbiology, Institut Pasteur, Université Paris Cité, Paris, France

  https://orcid.org/0000-0002-2509-6526

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