Patient stratification by genetic risk in Alzheimer’s disease is only effective in the presence of phenotypic heterogeneity

• Jack Euesden ,

  Contributed equally to this work with: Jack Euesden, Muhammad Ali

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jack.x.euesden@gsk.com

  Affiliation Biostatistics, GSK Pharma R&D, Stevenage, Hertfordshire, United Kingdom

  https://orcid.org/0000-0002-6790-1925

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• Muhammad Ali ,

  Contributed equally to this work with: Jack Euesden, Muhammad Ali

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, MO, United States of America

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• Chloe Robins,

  Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Genomic Sciences, GSK Pharma R&D, Collegeville, PA, United States of America

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• Praveen Surendran,

  Roles Writing – review & editing

  Affiliation Genomic Sciences, GSK Pharma R&D, Stevenage, Hertfordshire, United Kingdom

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• Padhraig Gormley,

  Roles Writing – review & editing

  Affiliation Genomic Sciences, GSK Pharma R&D, Cambridge, MA, United States of America

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• for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) ,

  ¶Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf

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• David Pulford ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  ¶‡ DP and CC also contributed equally to this work.

  Affiliation Genomic Sciences, GSK Pharma R&D, Stevenage, Hertfordshire, United Kingdom

  https://orcid.org/0000-0002-6998-4883

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• Carlos Cruchaga

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ DP and CC also contributed equally to this work.

  Affiliation Washington University School of Medicine, NeuroGenomics and Informatics Center, St. Louis, MO, United States of America

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