The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice

• Hakim Ben Abdallah ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  * E-mail: hba@clin.au.dk

  Affiliation Department of Dermatology, Aarhus University Hospital, Aarhus N, Denmark

  https://orcid.org/0000-0002-4610-5428

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• Giorgia Marino,

  Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedicine, Aarhus University, Aarhus C, Denmark

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• Manja Idorn,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedicine, Aarhus University, Aarhus C, Denmark

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• Line S. Reinert,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedicine, Aarhus University, Aarhus C, Denmark

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• Anne Bregnhøj,

  Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Dermatology, Aarhus University Hospital, Aarhus N, Denmark

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• Søren Riis Paludan,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Biomedicine, Aarhus University, Aarhus C, Denmark

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• Claus Johansen

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Dermatology, Aarhus University Hospital, Aarhus N, Denmark

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