Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways

Binmei Zhang; Jingxiu Hou; Jiaren Liu; Junhui He; Yunan Gao; Guangnan Li; Tianjiao Ma; Xin Lv; Li Dong; Wei Yang

doi:10.1371/journal.pone.0310852

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Open Access

Peer-reviewed

Research Article

Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways

Binmei Zhang,

Roles Conceptualization, Methodology, Software, Writing – review & editing

Affiliation Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
⨯
Jingxiu Hou,

Roles Data curation, Writing – original draft

Affiliation Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Jiaren Liu,

Roles Conceptualization, Methodology, Software

Affiliation Department of Clinical Lab, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China

https://orcid.org/0000-0001-6653-0053

⨯
Junhui He,

Roles Investigation, Visualization

Affiliation Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
⨯
Yunan Gao,

Roles Supervision

Affiliation Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
⨯
Guangnan Li,

Roles Supervision

Affiliation Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
⨯
Tianjiao Ma,

Roles Software, Validation

Affiliation Department of Cardiology, Nangang Branch of Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China
⨯
Xin Lv,

Roles Software, Validation

Affiliation Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
⨯
Li Dong ,

Roles Investigation, Visualization

* E-mail: dongli127@163.com (LD); hydyangwei@hrbmu.edu.cn (WY)

Affiliation Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
⨯
Wei Yang

Roles Conceptualization, Methodology, Software

* E-mail: dongli127@163.com (LD); hydyangwei@hrbmu.edu.cn (WY)

Affiliation Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China

https://orcid.org/0000-0001-7103-8784

⨯

Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways

Binmei Zhang,
Jingxiu Hou,
Jiaren Liu,
Junhui He,
Yunan Gao,
Guangnan Li,
Tianjiao Ma,
Xin Lv,
Li Dong,
Wei Yang

Published: January 8, 2025
https://doi.org/10.1371/journal.pone.0310852

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