CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization

Gowtham A. Rao; Azza Shoaibi; Rupa Makadia; Jill Hardin; Joel Swerdel; James Weaver; Erica A. Voss; Mitchell M. Conover; Stephen Fortin; Anthony G. Sena; Chris Knoll; Nigel Hughes; James P. Gilbert; Clair Blacketer; Alan Andryc; Frank DeFalco; Anthony Molinaro; Jenna Reps; Martijn J. Schuemie; Patrick B. Ryan

doi:10.1371/journal.pone.0310634

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Open Access

Peer-reviewed

Research Article

CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization

Gowtham A. Rao ,

Contributed equally to this work with: Gowtham A. Rao, Azza Shoaibi, Martijn J. Schuemie, Patrick B. Ryan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: GRao9@ITS.JNJ.com

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0002-4949-7236

⨯
Azza Shoaibi ,

Contributed equally to this work with: Gowtham A. Rao, Azza Shoaibi, Martijn J. Schuemie, Patrick B. Ryan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0002-6976-2594

⨯
Rupa Makadia,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Jill Hardin,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0003-2682-2187

⨯
Joel Swerdel,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
James Weaver,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0003-0755-5191

⨯
Erica A. Voss,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Mitchell M. Conover,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Stephen Fortin,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Anthony G. Sena,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0001-8630-5347

⨯
Chris Knoll,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Nigel Hughes,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
James P. Gilbert,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0003-2294-3459

⨯
Clair Blacketer,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Alan Andryc,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Frank DeFalco,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Anthony Molinaro,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
⨯
Jenna Reps,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America

https://orcid.org/0000-0002-2970-0778

⨯
Martijn J. Schuemie ,

Contributed equally to this work with: Gowtham A. Rao, Azza Shoaibi, Martijn J. Schuemie, Patrick B. Ryan

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America, Department of Biostatistics, University of California, Los Angeles, CA, United States of America

https://orcid.org/0000-0002-0817-5361

⨯
[ ... ],
Patrick B. Ryan

Contributed equally to this work with: Gowtham A. Rao, Azza Shoaibi, Martijn J. Schuemie, Patrick B. Ryan

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America, OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America, Department of Biomedical Informatics, Columbia University, New York, NY, United States of America
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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization

Gowtham A. Rao,
Azza Shoaibi,
Rupa Makadia,
Jill Hardin,
Joel Swerdel,
James Weaver,
Erica A. Voss,
Mitchell M. Conover,
Stephen Fortin,
Anthony G. Sena

Published: January 16, 2025
https://doi.org/10.1371/journal.pone.0310634

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