Hit screening with multivariate robust outlier detection

Hui Sun Leong; Tianhui Zhang; Adam Corrigan; Alessia Serrano; Ulrike Künzel; Niamh Mullooly; Ceri Wiggins; Yinhai Wang; Steven Novick

doi:10.1371/journal.pone.0310433

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Open Access

Peer-reviewed

Research Article

Hit screening with multivariate robust outlier detection

Hui Sun Leong ,

Contributed equally to this work with: Hui Sun Leong, Steven Novick

Roles Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: huisun.leong@astrazeneca.com

Affiliation Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

https://orcid.org/0000-0003-0890-6432

⨯
Tianhui Zhang,

Roles Methodology, Software, Writing – review & editing

Affiliation Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States of America
⨯
Adam Corrigan,

Roles Formal analysis, Methodology, Software, Writing – review & editing

Affiliation Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⨯
Alessia Serrano,

Roles Resources

Affiliation Functional Genomics, Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⨯
Ulrike Künzel,

Roles Resources

Affiliation Functional Genomics, Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⨯
Niamh Mullooly,

Roles Resources

Affiliation Functional Genomics, Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⨯
Ceri Wiggins,

Roles Resources

Affiliation Functional Genomics, Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom
⨯
Yinhai Wang,

Roles Writing – review & editing

Affiliation Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

https://orcid.org/0000-0002-3671-4932

⨯
Steven Novick

Contributed equally to this work with: Hui Sun Leong, Steven Novick

Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Data Sciences and Quantitative Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States of America
⨯

Hit screening with multivariate robust outlier detection

Hui Sun Leong,
Tianhui Zhang,
Adam Corrigan,
Alessia Serrano,
Ulrike Künzel,
Niamh Mullooly,
Ceri Wiggins,
Yinhai Wang,
Steven Novick

Published: September 12, 2024
https://doi.org/10.1371/journal.pone.0310433

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