In vivo imaging and pharmacokinetics of percutaneously injected ultrasound and X-ray imageable thermosensitive hydrogel loaded with doxorubicin versus free drug in swine

• Jose F. Delgado ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jose.delgado@nih.gov

  Affiliations Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America, Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, Maryland, United States of America

  https://orcid.org/0009-0001-8495-2783

  ⨯
• Ayele H. Negussie,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Nicole A. Varble,

  Roles Conceptualization, Data curation, Methodology, Software, Writing – review & editing

  Affiliations Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America, Philips Healthcare, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-2273-7962

  ⨯
• Andrew S. Mikhail,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Antonio Arrichiello,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America, Department of Diagnostic and Interventional Radiology, UOS of Interventional Ra `1diology, Ospedale Maggiore di Lodi, Lodi, Italy

  ⨯
• Tabea Borde,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Laetitia Saccenti,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  https://orcid.org/0000-0002-9765-0039

  ⨯
• Ivane Bakhutashvili,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Joshua W. Owen,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Robert Morhard,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• John W. Karanian,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• William F. Pritchard ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America

  https://orcid.org/0000-0001-5805-5344

  ⨯
• Bradford J. Wood

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Center for Interventional Oncology, Clinical Center, National Institutes of Health, Bethesda, MD, United States of America, Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, Maryland, United States of America

  ⨯