Ononin delays the development of osteoarthritis by down-regulating MAPK and NF-κB pathways in rat models

• Fang Xu ,

  Contributed equally to this work with: Fang Xu, Zhaocong Li, Yueming Jiang

  Roles Conceptualization, Data curation, Methodology, Writing – original draft

  Affiliations Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China

  https://orcid.org/0000-0002-4614-9279

  ⨯
• Zhaocong Li ,

  Contributed equally to this work with: Fang Xu, Zhaocong Li, Yueming Jiang

  Roles Data curation, Methodology, Project administration

  Affiliation Institute of Brain and Mental Diseases, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China

  ⨯
• Yueming Jiang ,

  Contributed equally to this work with: Fang Xu, Zhaocong Li, Yueming Jiang

  Roles Conceptualization, Formal analysis, Methodology, Validation

  Affiliations Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China, Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China

  ⨯
• Ting Liao,

  Roles Data curation, Formal analysis, Project administration

  Affiliations Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China, Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China

  ⨯
• Michael Aschner,

  Roles Writing – review & editing

  Affiliation Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America

  https://orcid.org/0000-0002-2619-1656

  ⨯
• Qingjun Wei

  Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: weiqingjun@gxmu.edu.cn

  Affiliation Department of Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

  https://orcid.org/0009-0006-7190-6469

  ⨯