A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice

Elisa Rossetti; Marija Vujadinovic; Ella van Huizen; Jeroen Tolboom; Hanneke Schuitemaker; Feng Yao; Roland Zahn; Eirikur Saeland

doi:10.1371/journal.pone.0310250

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Open Access

Peer-reviewed

Research Article

A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice

Elisa Rossetti,

Roles Conceptualization, Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Current address: Immunocore Ltd., Abingdon, United Kingdom

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands
⨯
Marija Vujadinovic,

Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands
⨯
Ella van Huizen,

Roles Data curation, Formal analysis, Methodology, Visualization

Current address: Leiden University Medical Center, Leiden, The Netherlands

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands
⨯
Jeroen Tolboom,

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands
⨯
Hanneke Schuitemaker,

Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing

Current address: Valneva SE, Saint-Herblain, France

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands
⨯
Feng Yao,

Roles Methodology, Resources, Writing – review & editing

Current address: SalioGen Therapeutics, Cambridge, MA, United States of America

Affiliation Brigham and Women’s Hospital, Boston, MA, United States of America
⨯
Roland Zahn ,

Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Validation, Writing – review & editing

* E-mail: rzahn@its.jnj.com (RZ); eirikursaeland@gmail.com (ES)

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands
⨯
Eirikur Saeland

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rzahn@its.jnj.com (RZ); eirikursaeland@gmail.com (ES)

Current address: Genmab, Utrecht, The Netherlands

Affiliation Janssen Vaccines & Prevention, Leiden, The Netherlands

https://orcid.org/0000-0002-7060-1181

⨯

A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice

Elisa Rossetti,
Marija Vujadinovic,
Ella van Huizen,
Jeroen Tolboom,
Hanneke Schuitemaker,
Feng Yao,
Roland Zahn,
Eirikur Saeland

Published: December 31, 2024
https://doi.org/10.1371/journal.pone.0310250

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