Methylome profiling of cell-free DNA during the early life course in (un)complicated pregnancies using MeD-seq: Protocol for a cohort study embedded in the prospective Rotterdam periconception cohort

• Marjolein M. van Vliet,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

  Affiliations Department of Obstetrics and Gynaecology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands, Department of Developmental Biology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

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• Sam Schoenmakers,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Obstetrics and Gynaecology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

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• Ruben G. Boers,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Visualization, Writing – review & editing

  Affiliation Department of Developmental Biology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

  https://orcid.org/0000-0002-3377-2897

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• Lotte E. van der Meeren,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliations Department of pathology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands, Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

  https://orcid.org/0000-0002-4537-5645

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• Joost Gribnau,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Developmental Biology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

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• Régine P. M. Steegers-Theunissen

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: r.steegers@erasmusmc.nl

  Affiliation Department of Obstetrics and Gynaecology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

  https://orcid.org/0000-0002-4353-5756

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