HEDGES co-prevents both SARS-CoV-2 and pandemic influenza infection in mice by rapid, durable co-production of twelve different anti-pandemic monoclonal antibodies

Marissa Mack; Alice Ye; Sarah Ursu; Ryan Ice; Liliana Soroceanu; Stan Shoor; Sean McAllister; Tim Heath; Chakkrapong Handumrongkul; Robert Debs

doi:10.1371/journal.pone.0309923

Loading metrics

Open Access

Peer-reviewed

Research Article

HEDGES co-prevents both SARS-CoV-2 and pandemic influenza infection in mice by rapid, durable co-production of twelve different anti-pandemic monoclonal antibodies

Marissa Mack ,

Contributed equally to this work with: Marissa Mack, Alice Ye

Roles Conceptualization, Data curation, Investigation, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Alice Ye ,

Contributed equally to this work with: Marissa Mack, Alice Ye

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Sarah Ursu,

Roles Data curation, Formal analysis, Investigation

Affiliation DNARx, San Francisco, California, United States of America
⨯
Ryan Ice,

Roles Data curation, Investigation, Methodology

Affiliation DNARx, San Francisco, California, United States of America
⨯
Liliana Soroceanu,

Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Stan Shoor,

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Sean McAllister,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Tim Heath,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Chakkrapong Handumrongkul,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation DNARx, San Francisco, California, United States of America
⨯
Robert Debs

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft

* E-mail: ninnatim@gmail.com

Affiliation DNARx, San Francisco, California, United States of America

https://orcid.org/0000-0001-9929-6267

⨯

HEDGES co-prevents both SARS-CoV-2 and pandemic influenza infection in mice by rapid, durable co-production of twelve different anti-pandemic monoclonal antibodies

Marissa Mack,
Alice Ye,
Sarah Ursu,
Ryan Ice,
Liliana Soroceanu,
Stan Shoor,
Sean McAllister,
Tim Heath,
Chakkrapong Handumrongkul,
Robert Debs

Published: January 23, 2026
https://doi.org/10.1371/journal.pone.0309923

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Intravenous injections
Is the Subject Area "Intravenous injections" applicable to this article?

Thanks for your feedback.
SARS CoV 2
Is the Subject Area "SARS CoV 2" applicable to this article?

Thanks for your feedback.
Plasmid construction
Is the Subject Area "Plasmid construction" applicable to this article?

Thanks for your feedback.
Serum proteins
Is the Subject Area "Serum proteins" applicable to this article?

Thanks for your feedback.
Pandemics
Is the Subject Area "Pandemics" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Plasmid vectors
Is the Subject Area "Plasmid vectors" applicable to this article?

Thanks for your feedback.
Influenza
Is the Subject Area "Influenza" applicable to this article?

Thanks for your feedback.