Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways

Jian-Bin Yin; Ying-Xia Wang; Su-Su Fan; Wen-Bin Shang; Yu-Shan Zhu; Xue-Rong Peng; Cheng Zou; Xuan Zhang

doi:10.1371/journal.pone.0309833

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Open Access

Peer-reviewed

Research Article

Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways

Jian-Bin Yin ,

Contributed equally to this work with: Jian-Bin Yin, Ying-Xia Wang, Su-Su Fan

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliations The People’s Hospital of ChuXiong Yi Autonomous Prefecture, ChuXiong, China, School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯
Ying-Xia Wang ,

Contributed equally to this work with: Jian-Bin Yin, Ying-Xia Wang, Su-Su Fan

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Pathology, the First Affiliated Hospital of Kunming Medical University, Kunming, China
⨯
Su-Su Fan ,

Contributed equally to this work with: Jian-Bin Yin, Ying-Xia Wang, Su-Su Fan

Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft

Affiliation School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯
Wen-Bin Shang,

Roles Methodology

Affiliation School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯
Yu-Shan Zhu,

Roles Methodology

Affiliation School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯
Xue-Rong Peng,

Roles Methodology

Affiliation School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯
Cheng Zou ,

Roles Supervision, Writing – review & editing

* E-mail: zouchengkm@126.com (ZC); snoopykm@126.com (XZ)

Affiliation School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯
Xuan Zhang

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: zouchengkm@126.com (ZC); snoopykm@126.com (XZ)

Affiliation School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, College of Modern Biomedical Industry, Kunming Medical University, Kunming, China
⨯

Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways

Jian-Bin Yin,
Ying-Xia Wang,
Su-Su Fan,
Wen-Bin Shang,
Yu-Shan Zhu,
Xue-Rong Peng,
Cheng Zou,
Xuan Zhang

Published: September 6, 2024
https://doi.org/10.1371/journal.pone.0309833

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