Optimized method development and validation for determining donepezil in rat plasma: A liquid-liquid extraction, LC-MS/MS, and design of experiments approach

• Ye Bin Shin ,

  Contributed equally to this work with: Ye Bin Shin, Jin Hwan Kim

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

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• Jin Hwan Kim ,

  Contributed equally to this work with: Ye Bin Shin, Jin Hwan Kim

  Roles Data curation, Investigation, Validation, Writing – original draft

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

  https://orcid.org/0009-0001-2040-1931

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• Min Kyeong Kwon,

  Roles Methodology, Resources

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

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• Jin Hyuk Myung,

  Roles Formal analysis, Investigation

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

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• Dong Geon Lee,

  Roles Formal analysis, Investigation

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

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• Sung Giu Jin,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pharmaceutical Engineering, Dankook University, Cheonan, Chungnam, South Korea

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• Myung Joo Kang ,

  Roles Conceptualization, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: kangmj@dankook.ac.kr (MJK); analysc@dankook.ac.kr (YSC)

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

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• Yong Seok Choi

  Roles Conceptualization, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: kangmj@dankook.ac.kr (MJK); analysc@dankook.ac.kr (YSC)

  Affiliation College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea

  https://orcid.org/0000-0001-6740-3160

  ⨯