Aβ_25-35-induced autophagy and apoptosis are prevented by the CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR signaling hub

• Yingshi Ji ,

  Contributed equally to this work with: Yingshi Ji, Jinghong Ren

  Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China

  ⨯
• Jinghong Ren ,

  Contributed equally to this work with: Yingshi Ji, Jinghong Ren

  Roles Conceptualization, Formal analysis, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China

  ⨯
• Yuan Qian,

  Roles Conceptualization, Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliation Beijing Jishuitan Hospital, Peking University Fourth School of Clinical Medicine, Beijing, PR China

  ⨯
• Jiaxin Li,

  Roles Conceptualization, Formal analysis, Visualization, Writing – review & editing

  Affiliation Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China

  ⨯
• Huanyu Liu,

  Roles Conceptualization, Formal analysis, Validation, Writing – review & editing

  Affiliation Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China

  ⨯
• Yuan Yao,

  Roles Conceptualization, Formal analysis, Visualization, Writing – review & editing

  Affiliation Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China

  ⨯
• Jianfeng Sun,

  Roles Formal analysis, Project administration, Writing – review & editing

  Affiliation Department of Physiology, Jilin University, Changchun, Jilin, PR China

  ⨯
• Rajesh Khanna ,

  Roles Funding acquisition, Writing – review & editing

  * E-mail: r.khanna@ufl.edu (RK); sunli99@jlu.edu.cn (LS)

  Affiliations Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, United States of America, Pain and Addiction Therapeutics (PATH) Collaboratory, College of Medicine, University of Florida, Gainesville, Florida, United States of America

  ⨯
• Li Sun

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: r.khanna@ufl.edu (RK); sunli99@jlu.edu.cn (LS)

  Affiliation Department of Neurology and Neuroscience Center, The First Hospital, Jilin University, Changchun, Jilin, PR China

  https://orcid.org/0000-0003-1169-4653

  ⨯