Heavy water inhibits DNA double-strand break repairs and disturbs cellular transcription, presumably via quantum-level mechanisms of kinetic isotope effects on hydrolytic enzyme reactions

• Takeshi Yasuda ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Visualization, Writing – original draft

  * E-mail: yasuda.takeshi@qst.go.jp

  Affiliation Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan

  https://orcid.org/0000-0001-6812-3048

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• Nakako Nakajima,

  Roles Investigation, Visualization

  Affiliation QST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan

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• Tomoo Ogi,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

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• Tomoko Yanaka,

  Roles Investigation, Visualization

  Affiliation Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan

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• Izumi Tanaka,

  Roles Investigation

  Affiliation Institute for Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba, Japan

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• Takaya Gotoh,

  Roles Funding acquisition, Investigation

  Affiliation Department of Health Science, Daito Bunka University, Saitama, Japan

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• Wataru Kagawa,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Interdisciplinary Science and Engineering, Program in Chemistry and Life Science, School of Science and Engineering, Meisei University, Tokyo, Japan

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• Kaoru Sugasawa,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Biosignal Research Center, and Graduate School of Science, Kobe University, Kobe, Japan

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• Katsushi Tajima

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Hematology, Yamagata Prefectural Central Hospital, Yamagata, Japan

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