Relationships between anxiety, depression and wound healing outcomes in adults: A systematic review and meta-analysis

Fiona O’Donovan; Lora Capobianco; Joseph Taylor-Bennett; Adrian Wells

doi:10.1371/journal.pone.0309683

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Open Access

Peer-reviewed

Research Article

Relationships between anxiety, depression and wound healing outcomes in adults: A systematic review and meta-analysis

Fiona O’Donovan,

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliations Division of Psychological Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, Psychosocial Service, Manchester University NHS Foundation Trust, Manchester, United Kingdom
⨯
Lora Capobianco,

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations Division of Psychological Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, Department of Research and Innovation, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom

https://orcid.org/0000-0001-6877-8650

⨯
Joseph Taylor-Bennett,

Roles Methodology

Affiliations Division of Psychological Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, Manchester Specialist Psychotherapy Service, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom
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Adrian Wells

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Adrian.wells@manchester.ac.uk

Affiliations Division of Psychological Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, Department of Research and Innovation, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom, Greater Manchester Mental Health NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

https://orcid.org/0000-0001-7713-1592

⨯

Relationships between anxiety, depression and wound healing outcomes in adults: A systematic review and meta-analysis

Fiona O’Donovan,
Lora Capobianco,
Joseph Taylor-Bennett,
Adrian Wells

Published: May 20, 2025
https://doi.org/10.1371/journal.pone.0309683

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Wound healing
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Depression
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Ulcers
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Anxiety
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Surgical and invasive medical procedures
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Anxiety disorders
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Metaanalysis
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Geriatric depression
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