Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone

• Francesca Catto ,

  Contributed equally to this work with: Francesca Catto, Daniel Kirschenbaum, Ehsan Dadgar-Kiani

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, IMAI MedTech GmbH, Zurich, Switzerland

  https://orcid.org/0000-0002-0429-2552

  ⨯
• Daniel Kirschenbaum ,

  Contributed equally to this work with: Francesca Catto, Daniel Kirschenbaum, Ehsan Dadgar-Kiani

  Roles Conceptualization, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  ⨯
• Athena E. Economides,

  Roles Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  https://orcid.org/0000-0003-2340-6364

  ⨯
• Anna Maria Reuss,

  Roles Methodology

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  https://orcid.org/0000-0003-1096-3030

  ⨯
• Chiara Trevisan,

  Roles Validation

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  https://orcid.org/0000-0002-3997-094X

  ⨯
• Davide Caredio,

  Roles Data curation, Formal analysis

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  https://orcid.org/0000-0002-3723-894X

  ⨯
• Ehsan Dadgar-Kiani ,

  Contributed equally to this work with: Francesca Catto, Daniel Kirschenbaum, Ehsan Dadgar-Kiani

  Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  Affiliations Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

  ⨯
• Delic Mirzet,

  Roles Methodology

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  ⨯
• Lukas Frick,

  Roles Data curation, Formal analysis, Visualization

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  ⨯
• Ulrike Weber-Stadlbauer,

  Roles Data curation, Methodology, Resources, Writing – review & editing

  Affiliations Institute of Veterinary Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

  ⨯
• Sergey Litvinov,

  Roles Methodology, Software

  Affiliation Computational Science and Engineering Laboratory, School of Engineering and Applied Sciences, Harvard University, Cambridge, United States of America

  ⨯
• Petros Koumoutsakos,

  Roles Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Computational Science and Engineering Laboratory, School of Engineering and Applied Sciences, Harvard University, Cambridge, United States of America

  ⨯
• Jin Hyung Lee ,

  * E-mail: adriano.aguzzi@uzh.ch (AA); ljinhy@stanford.edu (JHL)

  ¶‡ JHL and AA also contributed equally to this work.

  Affiliations Department of Neurology and Neurological Sciences, Stanford University, California, United States of America, Department of Bioengineering, Stanford University, Stanford, California, United States of America, Department of Electrical Engineering, Stanford University, Stanford, California, United States of America, Department of Neurosurgery, Stanford University, Stanford, California, United States of America

  ⨯
• Adriano Aguzzi

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: adriano.aguzzi@uzh.ch (AA); ljinhy@stanford.edu (JHL)

  ¶‡ JHL and AA also contributed equally to this work.

  Affiliation Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

  https://orcid.org/0000-0002-0344-6708

  ⨯