Investigating the effects of a daily multidisciplinary intensive outpatient rehabilitation program on innovative biomarkers in people with Parkinson’s disease: Study protocol for a phase III randomized controlled clinical trial

Francesca Lea Saibene; Cristina Agliardi; Anna Salvatore; Pietro Arcuri; Anna Castagna; Silvia Gobbo; Federico Merlo; Thomas Bowman; Denise Anastasi; Chiara Pagliari; Elisabetta Farina; Margherita Alberoni; Elena Calabrese; Francesca La Rosa; Chiara Arienti; Marina Saresella; Franca Rosa Guerini; Davide Cattaneo; Francesca Baglio; Mario Clerici; Jorge Navarro; Mario Meloni

doi:10.1371/journal.pone.0309405

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Investigating the effects of a daily multidisciplinary intensive outpatient rehabilitation program on innovative biomarkers in people with Parkinson’s disease: Study protocol for a phase III randomized controlled clinical trial

Francesca Lea Saibene,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Cristina Agliardi,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Anna Salvatore ,

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

* E-mail: asalvatore@dongnocchi.it

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy

https://orcid.org/0000-0002-7655-3555

⨯
Pietro Arcuri,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Anna Castagna,

Roles Investigation, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Silvia Gobbo,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Federico Merlo,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Thomas Bowman,

Roles Data curation, Investigation, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Denise Anastasi,

Roles Investigation, Writing – review & editing

Affiliation Department of Biomedical Sciences, University of Sassari, Sassari, Italy
⨯
Chiara Pagliari,

Roles Investigation, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy

https://orcid.org/0000-0002-2801-9550

⨯
Elisabetta Farina,

Roles Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Margherita Alberoni,

Roles Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Elena Calabrese,

Roles Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Francesca La Rosa,

Roles Investigation, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Chiara Arienti,

Roles Funding acquisition, Methodology, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Marina Saresella,

Roles Methodology, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Franca Rosa Guerini,

Roles Methodology, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Davide Cattaneo,

Roles Methodology, Writing – review & editing

Affiliations IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, Department of Physiopathology and Transplants, University of Milan, Milan, Italy
⨯
Francesca Baglio,

Roles Investigation, Methodology, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
Mario Clerici,

Roles Supervision, Writing – review & editing

Affiliations IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, Department of Physiopathology and Transplants, University of Milan, Milan, Italy
⨯
Jorge Navarro,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy
⨯
[ ... ],
Mario Meloni

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Neurology Unit, Azienda Ospedaliero-Universitaria, Cagliari, Italy
⨯
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Investigating the effects of a daily multidisciplinary intensive outpatient rehabilitation program on innovative biomarkers in people with Parkinson’s disease: Study protocol for a phase III randomized controlled clinical trial

Francesca Lea Saibene,
Cristina Agliardi,
Anna Salvatore,
Pietro Arcuri,
Anna Castagna,
Silvia Gobbo,
Federico Merlo,
Thomas Bowman,
Denise Anastasi,
Chiara Pagliari

Published: October 23, 2024
https://doi.org/10.1371/journal.pone.0309405

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