Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-T_SCM cells using a Quantum pBac-based CAR-T engineering system

• Peter S. Chang ,

  Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ PSC, YCC and WKH are contributed equally to this work and their authorship order is interchangeable.

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

  https://orcid.org/0000-0003-2034-3986

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• Yi-Chun Chen ,

  Roles Data curation, Formal analysis, Investigation

  ¶‡ PSC, YCC and WKH are contributed equally to this work and their authorship order is interchangeable.

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Wei-Kai Hua ,

  Roles Data curation, Formal analysis, Investigation, Validation

  ¶‡ PSC, YCC and WKH are contributed equally to this work and their authorship order is interchangeable.

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Jeff C. Hsu,

  Roles Formal analysis, Writing – review & editing

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Jui-Cheng Tsai,

  Roles Data curation, Investigation

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Yi-Wun Huang,

  Roles Data curation, Investigation

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Yi-Hsin Kao,

  Roles Data curation, Investigation

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Pei-Hua Wu,

  Roles Data curation, Investigation

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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• Po-Nan Wang,

  Roles Data curation

  Affiliation Division of Hematology, Chang Gung Medical Foundation, Linkou Branch, Taipei City, Taiwan (R.O.C.)

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• Yi-Fang Chang,

  Roles Data curation, Investigation

  Affiliations Division of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan (R.O.C.), Department of Medical Research, Laboratory of Good Clinical Research Center, Mackay Memorial Hospital, Tamsui District, New Taipei City, Taiwan (R.O.C.), Department of Medicine, Mackay Medical College, New Taipei City, Taiwan (R.O.C.)

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• Ming-Chih Chang,

  Roles Data curation, Investigation

  Affiliation Division of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan (R.O.C.)

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• Yu-Cheng Chang,

  Roles Data curation, Investigation

  Affiliations Division of Hematology and Oncology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan (R.O.C.), Department of Medical Research, Laboratory of Good Clinical Research Center, Mackay Memorial Hospital, Tamsui District, New Taipei City, Taiwan (R.O.C.)

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• Shiou-Ling Jian,

  Roles Data curation, Investigation

  Affiliation OBI Pharma, Inc., Taipei, Taiwan (R.O.C.)

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• Jiann-Shiun Lai,

  Roles Data curation, Investigation

  Affiliation OBI Pharma, Inc., Taipei, Taiwan (R.O.C.)

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• Ming-Tain Lai,

  Roles Data curation, Investigation

  Affiliation OBI Pharma, Inc., Taipei, Taiwan (R.O.C.)

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• Wei-Cheng Yang,

  Roles Data curation, Investigation

  Affiliation OBI Pharma, Inc., Taipei, Taiwan (R.O.C.)

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• Chia-Ning Shen,

  Roles Data curation, Investigation

  Affiliations Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan (R.O.C.), Genomics Research Center, Academia Sinica, Taipei, Taiwan (R.O.C.)

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• Kuo-Lan Karen Wen ,

  Roles Formal analysis

  * E-mail: sareina@genomefrontier.com (SCYW); klwen@genomefrontier.com (KLKW)

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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•  [ ... ],
• Sareina Chiung-Yuan Wu

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: sareina@genomefrontier.com (SCYW); klwen@genomefrontier.com (KLKW)

  Affiliation GenomeFrontier Therapeutics TW Co., Ltd., Taipei City, Taiwan (R.O.C.)

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