Update on a brain-penetrant cardiac glycoside that can lower cellular prion protein levels in human and guinea pig paradigms

• Shehab Eid,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Wenda Zhao,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Declan Williams,

  Roles Investigation, Methodology, Validation

  Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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• Zahra Nasser,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

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• Jennifer Griffin,

  Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada

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• Pavel Nagorny,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0002-7043-984X

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• Gerold Schmitt-Ulms

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: g.schmittulms@utoronto.ca

  Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0001-6962-0919

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