Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis

Fanchen Wang; Jiacong Xiao; Miao Li; Qi He; Xintian Wang; Zhaofeng Pan; Shaocong Li; Haibin Wang; Chi Zhou

doi:10.1371/journal.pone.0308731

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Open Access

Peer-reviewed

Research Article

Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis

Fanchen Wang,

Roles Writing – original draft, Writing – review & editing

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China

https://orcid.org/0000-0001-9824-641X

⨯
Jiacong Xiao,

Roles Visualization, Writing – original draft

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Miao Li,

Roles Conceptualization

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Qi He,

Roles Conceptualization, Data curation

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Xintian Wang,

Roles Conceptualization

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Zhaofeng Pan,

Roles Methodology

Affiliation The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Shaocong Li,

Roles Conceptualization, Project administration, Software

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, The Laboratory of Orthopedics and Traumatology of Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Haibin Wang ,

Roles Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: hipknee@163.com (HW); zcmzy1@163.com (CZ)

Affiliations First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China, Department of Orthopedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Chi Zhou

Roles Conceptualization

* E-mail: hipknee@163.com (HW); zcmzy1@163.com (CZ)

Affiliations Department of Orthopedic Surgery, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China, Maoming Hospital of Guangzhou University of Chinese Medicine, Maoming, China

https://orcid.org/0000-0003-1905-9494

⨯

Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis

Fanchen Wang,
Jiacong Xiao,
Miao Li,
Qi He,
Xintian Wang,
Zhaofeng Pan,
Shaocong Li,
Haibin Wang,
Chi Zhou

Published: August 29, 2024
https://doi.org/10.1371/journal.pone.0308731

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Chondrocytes
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Osteoarthritis
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Inflammation
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Inflammasomes
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Immune receptor signaling
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MAPK signaling cascades
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Cartilage
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Immunofluorescence
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