A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model

• Ruta Maciulaitiene ,

  Contributed equally to this work with: Ruta Maciulaitiene, Giedrius Kalesnykas, Dainius Haroldas Pauza, Ingrida Januleviciene

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ruta.maciulaitiene@lsmuni.lt

  Affiliation Department of Ophthalmology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

  https://orcid.org/0009-0002-1658-7849

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• Giedrius Kalesnykas ,

  Contributed equally to this work with: Ruta Maciulaitiene, Giedrius Kalesnykas, Dainius Haroldas Pauza, Ingrida Januleviciene

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Experimentica Ltd., Kuopio, Finland, Experimentica UAB, Vilnius, Lithuania, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

  ⨯
• Dainius Haroldas Pauza ,

  Contributed equally to this work with: Ruta Maciulaitiene, Giedrius Kalesnykas, Dainius Haroldas Pauza, Ingrida Januleviciene

  Roles Methodology, Resources, Supervision, Visualization, Writing – review & editing

  Affiliation Academy of Medicine, Institute of Anatomy, Lithuanian University of Health Sciences, Kaunas, Lithuania

  ⨯
• Ingrida Januleviciene

  Contributed equally to this work with: Ruta Maciulaitiene, Giedrius Kalesnykas, Dainius Haroldas Pauza, Ingrida Januleviciene

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Ophthalmology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania

  https://orcid.org/0000-0002-2660-7922

  ⨯