Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets

Yuan Tian; Nicolette Heinsinger; Yinghui Hu; U-Ming Lim; Yi Wang; Aaron Zefrin Fernandis; Sophie Parmentier-Batteur; Becky Klein; Jason M. Uslaner; Sean M. Smith

doi:10.1371/journal.pone.0308428

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Open Access

Peer-reviewed

Research Article

Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets

Yuan Tian ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: yuan.tian1@merck.com

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America

https://orcid.org/0000-0001-8158-1588

⨯
Nicolette Heinsinger,

Roles Data curation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America

https://orcid.org/0000-0002-7281-8800

⨯
Yinghui Hu,

Roles Data curation, Formal analysis, Methodology

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America
⨯
U-Ming Lim,

Roles Data curation, Formal analysis, Methodology

Affiliation Quantatitive Biosciences, Merck Sharp & Dohme, Singapore, Singapore
⨯
Yi Wang,

Roles Data curation, Formal analysis, Methodology

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America
⨯
Aaron Zefrin Fernandis,

Roles Conceptualization, Methodology, Supervision

Affiliation Quantatitive Biosciences, Merck Sharp & Dohme, Singapore, Singapore
⨯
Sophie Parmentier-Batteur,

Roles Conceptualization, Methodology, Resources

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America
⨯
Becky Klein,

Roles Supervision

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America
⨯
Jason M. Uslaner,

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America
⨯
Sean M. Smith

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Neuroscience, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, United States of America
⨯

Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets

Yuan Tian,
Nicolette Heinsinger,
Yinghui Hu,
U-Ming Lim,
Yi Wang,
Aaron Zefrin Fernandis,
Sophie Parmentier-Batteur,
Becky Klein,
Jason M. Uslaner,
Sean M. Smith

Published: December 31, 2024
https://doi.org/10.1371/journal.pone.0308428

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