Substitution of acidic residues near the catalytic Glu131 leads to human HYAL1 activity at neutral pH via charge-charge interactions

• Tu Anh Nguyen,

  Roles Investigation, Writing – original draft

  Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

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• Trang Hoang,

  Roles Investigation

  Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

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• Thu-Thuy Nguyen,

  Roles Investigation

  Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

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• ChanSu Jeong,

  Roles Investigation

  Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

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• Trang Van Tran,

  Roles Investigation

  Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

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• Mal-Gi Choi,

  Roles Writing – review & editing

  Affiliation Odysgen Inc., Daegu, South Korea

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• ChangWoo Lee

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  * E-mail: leec@daegu.ac.kr

  Affiliation Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University, Gyeongsan, South Korea

  https://orcid.org/0000-0002-0872-4500

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