Methods for analytical validation of novel digital clinical measures: A simulation study

• Simon Turner ,

  Contributed equally to this work with: Simon Turner, Chen Chen

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: simon.turner@dimesociety.org (ST); benjamin.vandendriessche@dimesociety.org (BV)

  Affiliation Digital Medicine Society (DiMe), Boston, Massachusetts, United States of America

  https://orcid.org/0009-0002-3801-1875

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• Chen Chen ,

  Contributed equally to this work with: Simon Turner, Chen Chen

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Verily Life Sciences, South San Francisco, California, United States of America

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• Rolando Acosta,

  Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America

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• Rachell Chon,

  Roles Project administration, Writing – review & editing

  Affiliation College of Osteopathic Medicine, Rocky Vista University, Utah, United States of America

  https://orcid.org/0009-0008-0437-0080

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• Eric J. Daza,

  Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Stats-of-1, Menlo Park, California, United States of America

  https://orcid.org/0000-0002-8376-1600

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• Lysbeth Floden,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Evinova, Waltham, Massachusetts, United States of America

  https://orcid.org/0000-0003-0584-6227

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• Joss Langford,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliations Activinsights Ltd., Kimbolton, United Kingdom, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom

  https://orcid.org/0000-0002-3204-5866

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• Leif Simmatis,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Speech-Language Pathology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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• Berend Terluin,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliations Department of General Practice, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands, Amsterdam Public Health research institute, Amsterdam, The Netherlands

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• Benjamin Vandendriessche ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: simon.turner@dimesociety.org (ST); benjamin.vandendriessche@dimesociety.org (BV)

  Affiliations Digital Medicine Society (DiMe), Boston, Massachusetts, United States of America, Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-0672-0327

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• Piper Fromy

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Digital Medicine Society (DiMe), Boston, Massachusetts, United States of America

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