Cancer-wide in silico analyses using differentially expressed genes demonstrate the functions and clinical relevance of JAG, DLL, and NOTCH

Jung Yun Kim; Nayoung Hong; Seok Won Ham; Sehyeon Park; Sunyoung Seo; Hyunggee Kim

doi:10.1371/journal.pone.0307943

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Open Access

Peer-reviewed

Research Article

Cancer-wide in silico analyses using differentially expressed genes demonstrate the functions and clinical relevance of JAG, DLL, and NOTCH

Jung Yun Kim,

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliations Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea, Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea
⨯
Nayoung Hong,

Roles Investigation, Writing – review & editing

Affiliations Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea, Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea
⨯
Seok Won Ham,

Roles Investigation, Writing – review & editing

Affiliation MEDIFIC Inc., Hwaseong-si, Gyeonggi-do, Republic of Korea
⨯
Sehyeon Park,

Roles Investigation, Writing – review & editing

Affiliations Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea, Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea
⨯
Sunyoung Seo,

Roles Investigation, Writing – review & editing

Affiliations Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea, Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea
⨯
Hyunggee Kim

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: hg-kim@korea.ac.kr

Affiliations Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea, Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea

https://orcid.org/0000-0002-5164-1663

⨯

Cancer-wide in silico analyses using differentially expressed genes demonstrate the functions and clinical relevance of JAG, DLL, and NOTCH

Jung Yun Kim,
Nayoung Hong,
Seok Won Ham,
Sehyeon Park,
Sunyoung Seo,
Hyunggee Kim

Published: July 29, 2024
https://doi.org/10.1371/journal.pone.0307943

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Notch signaling
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Lung and intrathoracic tumors
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Cancers and neoplasms
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Gene expression
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Malignant tumors
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Hepatocellular carcinoma
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Renal cancer
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Cancer treatment
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