shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice

Kamila Roszczyc-Owsiejczuk; Monika Imierska; Emilia Sokołowska; Mariusz Kuźmicki; Karolina Pogodzińska; Agnieszka Błachnio-Zabielska; Piotr Zabielski

doi:10.1371/journal.pone.0307802

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Open Access

Peer-reviewed

Research Article

shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice

Kamila Roszczyc-Owsiejczuk,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland

https://orcid.org/0000-0001-5296-5582

⨯
Monika Imierska,

Roles Conceptualization

Affiliation Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland
⨯
Emilia Sokołowska,

Roles Investigation

Affiliation Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland
⨯
Mariusz Kuźmicki,

Roles Investigation

Affiliation Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, Bialystok, Poland
⨯
Karolina Pogodzińska,

Roles Investigation

Affiliation Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland
⨯
Agnieszka Błachnio-Zabielska ,

Contributed equally to this work with: Agnieszka Błachnio-Zabielska, Piotr Zabielski

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

* E-mail: piotr.zabielski@umb.edu.pl (PZ); agnieszka.blachnio-zabielska@umb.edu.pl (AB-Z)

Affiliation Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland

https://orcid.org/0000-0002-8055-0576

⨯
Piotr Zabielski

Contributed equally to this work with: Agnieszka Błachnio-Zabielska, Piotr Zabielski

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

* E-mail: piotr.zabielski@umb.edu.pl (PZ); agnieszka.blachnio-zabielska@umb.edu.pl (AB-Z)

Affiliation Department of Medical Biology, Medical University of Bialystok, Bialystok, Poland

https://orcid.org/0000-0002-4901-5217

⨯

shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice

Kamila Roszczyc-Owsiejczuk,
Monika Imierska,
Emilia Sokołowska,
Mariusz Kuźmicki,
Karolina Pogodzińska,
Agnieszka Błachnio-Zabielska,
Piotr Zabielski

Published: August 23, 2024
https://doi.org/10.1371/journal.pone.0307802

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Skeletal muscles
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Insulin
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Muscle proteins
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Diet
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Gastrocnemius muscles
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Lipids
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Mitochondria
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Insulin signaling
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